Some Viruses Produce Insulin-Like Hormones

Scientists have identified four viruses that can produce insulin-like hormones that are active on human cells. The discovery brings new possibilities for revealing biological mechanisms that may cause diabetes or cancer.

Every cell in your body responds to the hormone insulin, and if that process starts to fail, you get diabetes. In an unexpected finding, scientists at Joslin Diabetes Center have identified four viruses that can produce insulin-like hormones that are active on human cells. The discovery brings new possibilities for revealing biological mechanisms that may cause diabetes or cancer.

"Our research may help open up a new field that we might call microbial endocrinology," says Emrah Altindis, PhD, a Joslin research fellow and lead author on a paper in the journal PNAS on the work. "We show that these viral insulin-like peptides can act on human and rodent cells. With the very large number of microbial peptides to which we are exposed, there is a novel window for host-microbe interactions. We hope that studying these processes will help us to better understand the role of microbes in human disease."

"Indeed, the discovery of the viral insulin-like hormones raises the question of what their role might be in diabetes, as well as autoimmune disease, cancer and other metabolic conditions," says C. Ronald Kahn, MD, Joslin's chief academic officer and senior author on the paper.

You may read the article in its entirety here:
https://www.sciencedaily.com/releases/2018/02/180219155012.htm