Alpacas Are Saving Lives
Alpacas aren’t the typical animals that drivers spot as they wind their way through rural Tennessee, but there’s a happy herd of them outside Waverly, where they eat the finest pellets, walk up and down a scenic hill and potentially save lives.
They’re owned by a team of Vanderbilt University researchers looking to harness their power to create unique antibodies usable to study human disease and potentially treat human patients. The team isolates fragments of these alpaca antibodies that can be used to visualize and potentially regulate the PPP2R5D enzyme, which has been linked to autism, Alzheimer’s disease and some cancers.
But on a visit to the farm on this unusually cool, spring day, Kim Wilson was more interested in what the alpacas could do for her son, Asa, 11, who was diagnosed with Jordan’s Syndrome – a rare genetic disorder caused by alterations in the PPP2R5D gene. The family had traveled from Mercer, Tennessee, to meet both the alpacas and scientists trying to find answers.
“I love watching them herd together, like a little family,” she said, petting an alpaca as she fed it by hand. Asa stood off to the side, more impressed by a toy airplane than the sometimes skittish pets. “I never thought they could help Asa in a way that could mean so much to my family. I’m just thankful for the scientists who know where to look for these things.”
Fewer than 100 children have been diagnosed with Jordan’s Syndrome – although advocates believe thousands more have been misdiagnosed with autism – marked by a series of developmental delays pegged to a single mutation in their PPP2R5D DNA. Wilson, who has older children, said her son exhibited signs almost immediately, although it took years for a diagnosis. He had no muscle tone and didn’t curl up like other babies, didn’t take his first steps until age 5 and still doesn’t speak in sentences.
He sees doctors at Monroe Carell Jr. Children’s Hospital at Vanderbilt, and that’s where Wilson learned about the alpaca research team.
Brian Wadzinski and Ben Spiller, both associate professors of pharmacology, and Rich Breyer, the Ruth King Scoville Chair in Medicine, came together through their shared fascination with alpacas’ potential to improve human health. They launched Turkey Creek Biotechnology as a platform to research that potential, purchased the herd and partnered with Litton Farms in Waverly to care for the animals.
A new drug to treat a blood disorder called acquired thrombotic thrombocytopenic purpura was developed using alpaca antibodies and gained FDA approval earlier this year. Wadzinski and his team know the possibilities go much further.
Vanderbilt University
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