Administration Set Change Chart
Regardless of infusate, change set immediately if contamination is suspected or product integrity is compromised. A sterile covering device should be used to cover the distal end of an administration set after intermittent use.
Administration Set Change Chart
| Administration Type | Administration Set | Set Change Frequency |
| Primary and Secondary Continuous Infusions (Infusions NOT containing blood, blood products or intravenous fat emulsions) |
Primary Set Secondary "piggyback" set |
If infusate is administered continuously via primary or secondary administration set, including add-on devices, change set(s) no more frequently than at 96 hour intervals, but at least every 7 days.1 Primary and secondary continuous administration sets should be changed no more frequently than every 96 hours.2 |
| Primary Intermittent Infusions (Infusions NOT containing blood, blood products or Intravenous fat emulsions) |
Primary Set | No frequency recommendation. Unresolved issue. 1 Replace set every 24 hours. 2 |
| Intravenous Fat Emulsion (IVFE) Use DEHP free tubing |
Primary Set Secondary "piggyback" set |
Within 24 hours of initiating the infusion.1 If infused separately, replace every 12 hours and/or with the with each new container.2 |
| TPN containing IVFE (3 in 1 formula) Use DEHP free tubing |
Primary Set | Replace every 24 hours and/or with the with each new container.2 |
| TPN (without IVFE) | Primary Set | No recommendation 1 Replace at least every 24 hours and with each new TPN/PN container. 2 |
| Blood / Blood Products | Primary Set Filter |
Replace within 24 hours of initiating the infusion. 1 Replace administration set and filter after the completion of each unit or every 4 hours. 2 |
| Propofol | Primary Set | Replace every 6 or 12 hours, when the vial is changed, per the manufacturer's recommendation.1 Replace every 6-12 hours per manufacturer instructions or when the container is changed 2 |
1 Recommendations from the Centers for Disease Control and Prevention (HICPAC)
2 Recommendations from the Infusion Nurse Society's 2016 Infusion Therapy Standards of Practice