Increasing knowledge about the underlying pathophysiology of myasthenia gravis is accelerating treatment development. These discoveries are being translated into meaningful improvement in the quality of life for patients afflicted with this disease. Not only are new medications within existing classifications and new medication combinations emerging, but whole new classes of medications are being developed at an exponentially advancing rate. This course presents a description of the disease, diagnosis, and various treatments. The material includes historical, current, and experimental interventions for control, or possible cure for this debilitating disease.
State Boards of Nursing have varying positions on the role of the LPN/LVN in the administration of infusion therapy, including the administration of antineoplastic agents. A link to each state board of nursing is listed here. Competency requirements are obtained and maintained through the nurse’s employer, facility, or institution.
Upon completion of this course, the nurse should be able to:
Describe the various myasthenia gravis serotypes.
Explain the basic pathophysiology responsible for generalized myasthenia gravis symptoms.
Distinguish among the various medication classifications used to treat generalized myasthenia gravis.
Name at least 3 medication classifications currently involved in clinical trials for the treatment of generalized myasthenia gravis.
Chapter 1: Introduction
Signs and Symptoms
Diagnosis
Symptom measurement
Serotypes
Membrane attack formation
Antibody recycling
Chapter 2: Treatment History
Discovery
Anticholinesterase inhibitors and thymectomy
Corticosteroids
Plasma exchange and IVIG
Chapter 3: Current Therapies
Complement inhibitors
FcRn blockers
B-cell therapies
Chapter 4: Clinical Trials
FcRn inhibitors
Complement inhibitors
B-cell depleting agents/CAR-T and CAAR-T
Chapter 5: References
Pamela Clark, CRNI, is an infusion nurse with the Houston Methodist Sugar Land Hospital. She has more than 35 years of experience in infusion therapy and infusion education with both licensed nurses and patients. Her experience spans multiple infusion settings including: acute care, long-term care, home infusion, and ambulatory infusion care. She also has experience in oncology and oncology research.
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